Scrip is part of Pharma Intelligence UK Limited

This site is operated by Pharma Intelligence UK Limited, a company registered in England and Wales with company number 13787459 whose registered office is 5 Howick Place, London SW1P 1WG. The Pharma Intelligence group is owned by Caerus Topco S.à r.l. and all copyright resides with the group.

This copy is for your personal, non-commercial use. For high-quality copies or electronic reprints for distribution to colleagues or customers, please call +44 (0) 20 3377 3183

Printed By

UsernamePublicRestriction

Pfizer Picks 'Off-The-Shelf' CAR-T And Backs TALEN Over CRISPR

This article was originally published in Scrip

Executive Summary

"Not as good as TALEN," was Cellectis's verdict on CRISPR gene editing, and it appears Pfizer concurs. The big pharma has licensed Cellectis's lead TALEN (not CRISPR) gene-edited CAR-T product candidate UCART19. Servier held an option on the rights, but exercised it early and handed it straight over to Pfizer.

You may also be interested in...



Second Cellectis CAR-T Therapy On Clinical Hold, Dosing Could Be Issue

A Phase I study for allogeneic therapy UCARTCS1A was put on clinical hold after a patient died. High dosing and double exposure to cyclophosphamide pre-conditioning may have played a role. 

Gilead/Kite Pricing For Yescarta Undercuts Novartis's CAR-T Kymriah

Gilead's newly acquired CAR-T therapy Yescarta, developed by Kite Pharma, won FDA approval for certain B cell lymphomas on Oct. 18 and the company set its price $102,000 below Novartis's competing therapy Kymriah, which was approved in a small pediatric leukemia indication.

Rising Tide Lifts All CAR-T Ships After Gilead/Kite Deal, Kymriah Approval

Excitement around cell therapy has been building in recent years, but companies expect interest to accelerate after Gilead agreed to buy Kite for $11.9bn and Novartis won the first ever CAR-T approval.

Topics

Latest Headlines
See All
UsernamePublicRestriction

Register

SC063748

Ask The Analyst

Ask the Analyst is free for subscribers.  Submit your question and one of our analysts will be in touch.

Thank you for submitting your question. We will respond to you within 2 business days. my@email.address.

All fields are required.

Please make sure all fields are completed.

Please make sure you have filled out all fields

Please make sure you have filled out all fields

Please enter a valid e-mail address

Please enter a valid Phone Number

Ask your question to our analysts

Cancel