Scrip is part of Informa PLC

This site is operated by a business or businesses owned by Informa PLC and all copyright resides with them. Informa PLC’s registered office is 5 Howick Place, London SW1P 1WG. Registered in England and Wales. Number 8860726.

This copy is for your personal, non-commercial use. For high-quality copies or electronic reprints for distribution to colleagues or customers, please call +44 (0) 20 3377 3183

Printed By


New research reveals frequency of mitochondrial mutations

This article was originally published in Scrip

Executive Summary

The incidence of DNA mutations that can cause mitochondrial disease is more common than previously believed, scientists say. According to research carried out at Newcastle University in the UK, and partially funded by The United Mitochondrial Disease Foundation (UMDF), one in every 200 people has a gene mutation that could lead to mitochondrial disease in them or their offspring. The discovery confirms what many researchers and experts have suspected for some time, establishing that the incidence of new mutations is relatively high and asymptomatic carriers are not rare. Mitochondrial diseases cover a range of illnesses, some of which are fatal, and mitochondrial disorders are at the core of many common diseases such as diabetes, cardiovascular disease, Parkinson's disease, Alzheimer’s disease and various cancers. Charles Mohan, executive director and CEO of UMDF believes the findings emphasise the need for more research into mitochondrial disease and dysfunction. The findings are published in the latest issue of the American Journal of Human Genetics (July 31st, p 254).






Ask The Analyst

Please Note: Click here for more information on the Ask the Analyst service.

Your question has been successfully sent to the email address below and we will get back as soon as possible. my@email.address.

All fields are required.

Please make sure all fields are completed.

Please make sure you have filled out all fields

Please make sure you have filled out all fields

Please enter a valid e-mail address

Please enter a valid Phone Number

Ask your question to our analysts