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OncoTherapy's lead project set to enter Phase II

This article was originally published in Scrip

Executive Summary

The Japanese bioventure OncoTherapy Science is to take its lead development project into Phase II clinical trials later this year following positive results in a domestic Phase I study. OTS102 is an angiogenesis-inhibiting therapy for colon and other cancers, which targets the VEGF receptor 2 over-expressed in tumour blood vessels. Its main component is KDR169, the main kinase domain receptor of VEGFR2, which induces cytotoxic T lymphocytes to attack tumour-associated neovascular endothelial cells expressing KDR. The Phase II programme should begin in the autumn, OncoTherapy said.

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