Scrip is part of Informa PLC

This site is operated by a business or businesses owned by Informa PLC and all copyright resides with them. Informa PLC’s registered office is 5 Howick Place, London SW1P 1WG. Registered in England and Wales. Number 8860726.

This copy is for your personal, non-commercial use. For high-quality copies or electronic reprints for distribution to colleagues or customers, please call +44 (0) 20 3377 3183

Printed By


AstraZeneca and Isis broaden antisense deal

This article was originally published in Scrip

Executive Summary

AstraZeneca and Isis Pharmaceuticals have expanded their alliance in the field of antisense therapies, with the UK major paying $65m up front to Isis as part of the agreement. They will collaborate to discover and develop new treatments for cardiovascular, metabolic and renal diseases, in a move that extends Isis's R&D into kidney disease, a new area for the company. The deal will also include development and regulatory milestones for each program that advances, as well as double-digit tiered royalties on net sales of any resulting products that are ultimately commercialized. The two companies first partnered to develop antisense therapies against cancer targets in 2012, in a collaboration that was worth $31m up front to Isis but which the company boasted could be ultimately worth in excess of $1bn. The following year that deal was expanded to include metabolic and cardiovascular indications. They later expanded their partnership to discover and develop novel delivery methods for antisense oligonucleotides in November 2014. The lead compound in the cancer collaboration, AZD9150/ISIS-STAT3-2.5Rx, targeting STAT3, has reached Phase II.

You may also be interested in...

AstraZeneca's License Of Ionis NASH Candidate Illustrates Still Hot Competition

Along with last week's acquisition of three NASH candidates from Lilly by Terns, NASH remains a heavily crowded R&D space as the European Association for the Study of the Liver annual meeting approaches.

Gaming Whiz Brings AI Smarts To Drug Discovery

GlamorousAI is developing technology to uncover new targets and take on previously intractable disease challenges. Founder Noor Shaker hopes to license a drug to big pharma within the next three years.

The Top 10 Best-Selling Drugs of 2019

INFOGRAPHIC: In 2019, 10 blockbuster medicines booked combined sales of $92.5bn. This infographic examines those drugs that commanded the greatest revenues globally, and answers some key questions. Which therapeutic areas include the most lucrative blockbusters? Which companies enjoyed their spoils? And which drugs were new to the top 10 last year? It also takes a look at the position of these products on the all-important US market. 


Related Companies




Ask The Analyst

Ask the Analyst is free for subscribers.  Submit your question and one of our analysts will be in touch.

Thank you for submitting your question. We will respond to you within 2 business days. my@email.address.

All fields are required.

Please make sure all fields are completed.

Please make sure you have filled out all fields

Please make sure you have filled out all fields

Please enter a valid e-mail address

Please enter a valid Phone Number

Ask your question to our analysts