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Roche/Evotec's Alzheimer's candidate fails

This article was originally published in Scrip

Executive Summary

Roche and Evotec look set to drop their MAO-B inhibitor sembragiline from development for Alzheimer's following disappointing Phase IIb data. The product appears to be a late swansong for this mechanism of action in Alzheimer's: previous similar candidates failed around 15 years ago, and the only other investigational MAO-B inhibitors still in the running are at the preclinical stage.



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