Scrip is part of the Informa Intelligence Division of Informa PLC

This site is operated by a business or businesses owned by Informa PLC and all copyright resides with them. Informa PLC’s registered office is 5 Howick Place, London SW1P 1WG. Registered in England and Wales. Number 8860726.

This copy is for your personal, non-commercial use. For high-quality copies or electronic reprints for distribution to colleagues or customers, please call +44 (0) 20 3377 3183

Printed By


Emergent BioSolutions to team its Ebola vaccine with GSK's in Phase I

This article was originally published in Scrip

Executive Summary

Emergent BioSolutions has completed the manufacture of the first clinical lot of a modified vaccinia Ankara (MVA) Ebola Zaire vaccine candidate (MVA EBOZ) that will be used in a Phase I trial together with GlaxoSmithKline's Chimp Adenovirus type 3 (ChAd3) Ebola vaccine candidate as a heterologous boost. The Phase I study will be conducted in the UK at the Jenner Institute in Oxford, supported by a grant from the Wellcome Trust and the UK Department for International Development. Under several agreements that it signed with the University of Oxford, GSK, and the US National Institutes of Health's National Institute of Allergy and Infectious Diseases (NIAID), Emergent has performed proof of concept work and manufactured the MVA EBOZ vaccine candidate at a 200L scale in an avian cell line. Manufacturing in this cell line has significant advantages including removing the requirement for eggs from the manufacturing process, consistency of manufactured vaccine lots, and increases in doses delivered, the company said. The scalable process has the potential to meet the demand for multi-million doses in a few months.



Related Companies




Ask The Analyst

Please Note: Click here for more information on the Ask the Analyst service.

Your question has been successfully sent to the email address below and we will get back as soon as possible. my@email.address.

All fields are required.

Please make sure all fields are completed.

Please make sure you have filled out all fields

Please make sure you have filled out all fields

Please enter a valid e-mail address

Please enter a valid Phone Number

Ask your question to our analysts