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Third time lucky for also-ran Arzerra

This article was originally published in Scrip

Executive Summary

GlaxoSmithKline/Genmab's Arzerra (ofatumumab) has shown improved progression-free survival (PFS) in a Phase III trial in relapsed chronic lymphocytic leukemia (CLL). The positive interim result in the Phase III PROLONG study comes after recent disappointments in which the CD20-targeting monoclonal antibody failed to improve PFS in a subgroup of patients with the disease (, 30 June 2014), while it also failed to meets its PFS target in another trial in diffuse large B-cell lymphoma (, 20 May 2014).



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