Scrip is part of Informa PLC

This site is operated by a business or businesses owned by Informa PLC and all copyright resides with them. Informa PLC’s registered office is 5 Howick Place, London SW1P 1WG. Registered in England and Wales. Number 8860726.

This copy is for your personal, non-commercial use. For high-quality copies or electronic reprints for distribution to colleagues or customers, please call +44 (0) 20 3377 3183

Printed By


Vernalis regains compounds from Serono

This article was originally published in Scrip

Executive Summary

Vernalishas regained the rights to certain compounds targeting inflammatory diseases, following the merger of Merck KGaA and Serono. These compounds were previously part of a licence, development and commercialisation agreement between Vernalis and Serono. The lead compound in the portfolio, V85546 (previously AS111793), is a selective MMP-12 inhibitor and has successfully completed Phase I clinical trials. Vernalis is determining the optimal Phase II development programme for V85546 and intends to conduct further development of the compound under a new collaborative agreement. V85546 could be developed for the treatment of several inflammatory diseases, including chronic obstructive pulmonary disease, acute respiratory distress syndrome and multiple sclerosis. If the compound does not display the joint-pain side-effects inherent in other previous drugs in this area, it could have significant potential, Piper Jaffray analysts said. The analysts added that Vernalis could become an attractive takeover target, potentially for a CNS-focused company, following its restructuring and given that it has sufficient cash to fund its pipeline through further trials. Vernalis's share price rose by £0.23 to close at £2.93 on October 22nd.

You may also be interested in...

Myotec and Hybrid merge to form PsiOxus

Myotec Therapeutics and Hybrid Biosystems are to merge to form PsiOxus Therapeutics with £3.6 million in funding from a syndicate led by the former's previous backer Imperial Innovations.

Trophos's MitoCare programme receives €6 million EU funding

A Phase II efficacy and safety study of Trophos' cholesterol-oxime compound TRO40303 to treat cardiac ischaemia-reperfusion injury in acute myocardial infarction patients will be substantially underwritten by funds from the European Union, the Marseilles-based company says. Trophos is to head a new 16-partner consortium called MitoCare, a 2.5 year international translational medicine project that has received a €6 million award under the European Union Seventh Framework Programme for research. The project will begin in January 2011.

Novartis and Alcon reach compromise to settle merger saga

Alcon's board of directors has finally approved a merger agreement with Novartis for the Alcon shares the latter does not already own, drawing a close to protracted negotiations that first began nearly a year ago.


Related Companies




Ask The Analyst

Please Note: Click here for more information on the Ask the Analyst service.

Your question has been successfully sent to the email address below and we will get back as soon as possible. my@email.address.

All fields are required.

Please make sure all fields are completed.

Please make sure you have filled out all fields

Please make sure you have filled out all fields

Please enter a valid e-mail address

Please enter a valid Phone Number

Ask your question to our analysts