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US FDA questions dose, safety of Titan's opioid-dependence implant

This article was originally published in Scrip

Executive Summary

US FDA drug reviewers on 19 March said the response of Titan Pharmaceuticals' Probuphine (buprenorphine hydrochloride/ethylene vinyl acetate) subdermal implant "was not what one might hope for" as a maintenance therapy to curtail dependence on opioids, such as Purdue Pharma's OxyContin (oxycodone hydrochloride controlled-release) and Endo's Percocet (oxycodone hydrochloride and acetaminophen) or even street drugs like heroin.


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