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Avastin unraveled by stratification study, Roche seeks validation

This article was originally published in Scrip

Executive Summary

  • Reanalysis of Avastin registration trial brings Roche strategy for making universal Avastin use in oncology into question again.
  • Study suggests less than half of Avastin treated colorectal cancer patients benefit from the drug.
  • Similar stratification may be demonstrated in other Avastin indication.
  • UK’s National Health Service could benefit financially from running confirmatory study.
  • Since Avastin is approved and reimbursed in colorectal cancer in many market, the UK where reimbursement is not automatic is one of the few markets where such a trial could be performed ethically.
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