Roche still hopeful it can prove Avastin benefits despite panel knock back
This article was originally published in Scrip
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Three projects that will drive future growth were highlighted at Bayer's Perspective on Innovation 2014 Meeting, held in Leverkusen on 2 December 2014. The company singled out the protein free formulation of its blockbuster hemophilia A therapy Kogenate (BAY 81-8973), regorafenib eye drops for wet age-related macular degeneration, and the androgen receptor inhibitor ODM-201, which is partnered with Orion.
Early Phase I/II trial data has restored hope that PARP inhibitors may be effective in treating cancer. The PARP inhibitor class took a hit from the failure of Sanofi's iniparib triple-negative breast cancer, but that molecule turned out not to be a PARP inhibitor at all. Now, according to data revealed at the European Cancer Congress (ECC) in Amsterdam on 29 September, around half of the heavily pretreated patients receiving Biomarin's BMN-673 demonstrated an objective response. BioMarin will begin a pivotal Phase III trial to determine the role of BMN-673 in the treatment of BRCA mutation-positive patients. The drug could become the first PARP inhibitor to gain approval for BRCA mutation-positive metastatic breast cancer.