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Contrave's future in doubt as US FDA demands another cardiac study

This article was originally published in Scrip

Executive Summary

The future of Orexigen Therapeutics/Takeda's obesity therapy Contrave (naltrexone HCl/bupropion HCl) looks highly uncertain after the US FDA said it wanted a further cardiovascular safety trial before it will approve the product. The request, outlined in a complete response letter, wiped more than 70% off of the US company's share price in early trading on 1 February.

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