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US panel to review safety concerns of IV phenytoin, fosphenytoin

This article was originally published in Scrip

Executive Summary

The US FDA's peripheral and central nervous system drugs advisory committee and the risk management advisory committee will meet on 3 November to discuss a number of safety concerns with intravenous administration of phenytoin and fosphenytoin, including the condition known as purple glove syndrome, which is a rare complication that typically causes pain, oedema, and discolouration at the injection site that spreads to the distal limb.






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