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PPIs linked with fractures and infection

This article was originally published in Scrip

Executive Summary

Proton pump inhibitors (PPIs) including AstraZeneca's Nexium (esomeprazole) and Takeda's Prevacid (lansoprazole) are associated with significant side effects that may outweigh their benefits, suggest a series of articles published in the Archives of Internal Medicine. Whereas one study showed that these drugs increased the risk of fracture by a modest 25%, another showed they increased the risk of Clostridium difficile infection by 75–136%.

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