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AstraZeneca's Recentin fails to show benefit over Roche's Avastin in Phase III colorectal cancer trial

This article was originally published in Scrip

Executive Summary

AstraZeneca is facing more disappointment with the development of its new anticancers after its experimental anti-angiogenic drug Recentin (cediranib) did not show non-inferiority in progression-free survival (PFS), or superiority, to Roche's Avastin (bevacizumab) when both were combined with chemotherapy in the pivotal Phase II/III HORIZON III trial in patients with first-line metastatic colorectal cancer (mCRC).



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