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Clozapine associated with lower mortality than newer antipsychotics, study finds

This article was originally published in Scrip

Executive Summary

The second-generation antipsychotic clozapine (Novartis's Clozaril and generics) has unexpectedly been seen to be associated with a lower mortality rate than an older first generation antipsychotic, perphenazine, while other newer second-generation antipsychotics, such as AstraZeneca's Seroquel (quetiapine) and J&J's Risperdal (risperidone), have been shown to be associated with increased mortality, in a population-based study published in The Lancet online on July 13th.



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